| AVS 66th International Symposium & Exhibition | |
| Advanced Ion Microscopy and Ion Beam Nano-engineering Focus Topic | Wednesday Sessions |
| Session HI+AS+CA-WeA |
| Session: | Advanced Ion Microscopy and Surface Analysis Applications |
| Presenter: | Natalie Frese, Bielefeld University, Germany |
| Authors: | N. Frese, Bielefeld University, Germany A. Beyer, Bielefeld University, Germany C. Kaltschmidt, Bielefeld University, Germany B. Kaltschmidt, Bielefeld University, Germany A. Thomas, Institute for Metallic Materials Dresden, Germany W. Parak, University of Hamburg, Germany A. Gölzhäuser, Bielefeld University, Germany |
| Correspondent: | Click to Email |
Studies from the last decade have shown that helium-ion microscopy (HIM) is suitable for studying biological samples. In particular, cell membranes can be imaged by HIM without metallic coatings, which could lead to disturbance of the surface. In this contribution, we give two examples of biological cells imaged by HIM: (i) mouse hippocampal neurons on patterned surfaces for neuronal networks and (ii) human cells treated with colloidal nanoparticles [1, 2]. Both examples benefit from the high resolution imaging of uncoated, biological materials by HIM, as for (i) the cell adherence to patterned surfaces could be imaged and for (ii) cell morphology images indicated harmful effects of colloidal nanoparticles to cells.
[1] M. Schürmann et al., PLoS ONE 13(2), e0192647 (2018)
[2] X. Ma et al., ACS Nano 11(8), 7807-7820 (2017)