AVS 52nd International Symposium
    Exhibitor Workshop Wednesday Sessions
       Session EW-WeL

Paper EW-WeL3
Latest Development  in Environmental Scanning Probe Microscope - Membrane of a HELA Cancer Cell

Wednesday, November 2, 2005, 12:40 pm, Room Exhibit Hall C&D

Session: XPS and SPM New Developments and Applications
Presenter: C. Wall, Molecular Imaging Corp.
Authors: S. Xu, Molecular Imaging Corp.
C. Wall, Molecular Imaging Corp.
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The presentation will focus on the following topics: a) the environmental AFM application in chemistry, material science and biomaterial research; b) Nanografting: fabrication of nanometer size patterns using AFM and the potential application in development of biosensors; c) Post-imaging data processing, data rendering and analytical techniques; d)nanometer level mechanical testing application in biological materials.  Many experiments benefit from imaging under controlled conditions: for biological applications imaging at 37 C is often crucial and controlled gas environments (oxygen, carbon dioxide  etc)  is frequently required. Electrochemical measurements are carried out in solution, mostly at the absence of dissolved oxygen, polymer studies are affected by humidity and temperature.  In-situ real time "nano-movies" can be taken at programmed changing temperature between -40 C to +250 C.  Various experimental results will be discussed using versatile imaging modes and under wide range of environmental controlling techniques.  The concept of AFM nanolithography includes a list of surface chemistry reactions that could be used to create nanometer level patterns using atomic force microscope.  Fabrication of nanometer size patterns attracted tremendous attention because patterned surfaces can be used as the building block for a wide range of research in developing biological sensors, nanodevices and masks for fabrication of nanoelectronics.  Through chemically active nanopatterning, surfaces can be engineered with nanoscale spatial resolution. The concept of NanoGrafting includes a wide range of SPM assisted nanolithography techniques which could yield nanometer size patterns with desired chemical functionality on a variety of substrates. AFM images not only give a topographic view of the sample surface with high resolution, post-imaging processing can also allow researchers to extract more quantitative information of the experiments.  Skillful data rendering not only can help the enhancement of spatial resolution, using Texture Mapping, advanced imaging mode data can be displayed with much more informative format and striking clarity.