Nanotechnology extends to all areas of research, from nanodevices to single molecular interactions. Scanning Probe Microscopy provides the perfect tool for nanostructuring and nanomanipulation, so that components such as nanoparticles, nanowires, atoms, and molecules can be analyzed and engineered to nanodevices for applications such as nanoelectronics, drug delivery and disease diagnoses. Molecular Imaging has invested more than 10 years of innovative research in the development of advanced scanning probe technology for controlled environments such as atmosphere, fluid and temperature. The workshop will focus on the application of PicoSPM® system in nanostructuring and nanomanipulation. Nanostructuring will demonstrate examples from both mechanical and electric lithography. Nanomanipulation will discuss examples of pushing and aligning of nanoparticals and nanowires. The study of electronic properties of single molecular wires, and conductive properties of thin films such as self-assembled monolayers with current sensing techniques will also be covered. An in depth review of PicoTREC@super TM@ will be presented. PicoTREC allows simultaneous imaging and mapping of single molecule interactions. Using PicoTREC, reasearchers can quickly distinguish between species that are engaged in molecular binding events and those that are not engaged in molecular binding events thus eliminating the need to perform slow and tedious force spectroscopy experiments to get the same results. It is now possible to conduct molecular recognition experiments with AFM easily and to get results in less time. Scientists can explore dynamic properties of biological systems such as antibody-antigen, ligand-receptor, drug-receptor, DNA-protein, and DNA-DNA.