Invited Paper PS+AS+EL+EM+SE-WeM12
Peter Mark Memorial Award: Plasma-bio Interactions: Investigating Mechanisms to Enable New Applications

Wednesday, October 24, 2018, 11:40 am, Room 104B

Cold non-equilibrium atmospheric pressure plasmas (CAPs) have received a lot of attention in the last decades due to their huge potential for biomedical applications including wound healing, cancer treatment, dental treatments and disinfection and decontamination of heat sensitive materials [1]. These applications are due to the near ambient gas temperature at which CAPs can be produced and their high reactivity, involving the production of numerous reactive oxygen and nitrogen species [2]. Many applications require controlled interactions of plasma with bacteria, virus and mammalian cells or tissue that enable selectivity between healthy and cancer cells or in the treatment of bacteria on healthy tissue or food samples for which off target effects needs to be minimized. A controlled selectivity might be the greatest challenge for these applications and requires a detailed understanding of the underlying plasma-bio-interaction mechanisms. In this framework, my group in collaboration with microbiologists has performed detailed studies of the interactions of CAP with virus, bacteria and mammalian cells. Our research shows that controlling the gas phase plasma chemistry can lead to significant different biological responses of the living organisms [3-6]. The outcomes of these studies allow unraveling chemical pathways responsible for plasma-bio interactions and linking plasma kinetics to plasma-bio interactions. These insights are of invaluable importance for the development of applications in the field of plasma medicine.

References

[1] I. Adamovich, S.D. Baalrud, A. Bogaerts et al, J. Phys. D: Appl. Phys. 50, 323001 (2017)

[2] D. B. Graves, J. Phys. D: Appl. Phys. 45, 263001 (2012).

[3] K. Wende, P. Williams, J. Dalluge et al. Biointerphases, 10 (2), 029548 (2015)

[4] H.A. Aboubakr, U. Gangal, M.M. Youssef, S.M. Goyal and P.J. Bruggeman, J. Phys. D: Appl. Phys. 49, 204001 (2016)

[5] G. Nayak, H.A. Aboubakr, S.M. Goyal and P.J. Bruggeman, Plasma Process. Polym. 15, 1700119 (2018)

[6] V.S.S.K. Kondeti, C. Phan, K. Wende, H. Jablonowski, U. Gangal, J. Granick, R.C. Hunter and P.J. Bruggeman (submitted)

Acknowledgements

This work is partially supported by the ”Plasma Science Center on Control of Plasma Kinetics” of the United States Department of Energy, Office of Fusion Energy Science (DE-SC0001319), the Agriculture and Food Research Initiative of the USDA`s National Institute of Food and Agriculture (2017-67017-26172) and a Department of Energy Early Career Research Award (DE-SC0016053).