AVS 61st International Symposium & Exhibition
    Atom Probe Tomography Focus Topic Friday Sessions
       Session AP+AS+NS+SS-FrM

Invited Paper AP+AS+NS+SS-FrM8
APT Analysis of Biological Materials

Friday, November 14, 2014, 10:40 am, Room 301

Session: Correlative Surface and Interface Analysis with APT
Presenter: Daniel Perea, Pacific Northwest National Laboratory
Authors: D.E. Perea, Pacific Northwest National Laboratory
J. Liu, Pacific Northwest National Laboratory
J.A. Bartrand, Pacific Northwest National Laboratory
N.D. Browning, Pacific Northwest National Laboratory
J.E. Evans, Pacific Northwest National Laboratory
Correspondent: Click to Email
Biointerfaces play an essential role for the function of many biological materials and organisms. The behaviors of complex macromolecular systems at materials interfaces are important in the fields of biology, environmental biology, biotechnology, and medicine. An understanding of the chemical processes and physics, and ultimate the ability to engineer biomaterials and microorganisms with specific properties and functions, is aided by an atomic level understanding of the composition and morphology of biointerfaces. However, a great challenge exists to map the atomic level composition and morphology of biointerfaces using APT, precluding a complete understanding of the structure properties relationship. At the Environmental Molecular Sciences Laboratory (EMSL), the application of APT is being developed in combination with other microscopy and spectroscopic techniques to study interfaces in biologic materials. We are developing methodologies and analyses that are allowing us to probe the ultimate limits of what APT analysis can confidently provide despite the complex thermally-assisted field evaporation behavior of soft materials. Advanced sample preparation techniques will also be discussed that further advance the application of APT into field of biology.