AVS 57th International Symposium & Exhibition
    MEMS and NEMS Thursday Sessions
       Session MN-ThA

Paper MN-ThA9
Development of Lab-on-a-chip on Mn Induced Nano-arrayed Structures in Sol-gel Derived TiO2 Platforms for Biosensing Applications

Thursday, October 21, 2010, 4:40 pm, Room Santo Domingo

Session: Integration, Packaging and Reliability of MEMS and NEMS
Presenter: M. Dhayal, Centre for Cellular and Molecular Biology, India
Authors: R.R. Pandey, Centre for Cellular and Molecular Biology, India
K.K. Saini, National Physical Laboratory, India
M. Dhayal, Centre for Cellular and Molecular Biology, India
Correspondent: Click to Email
Development of low cost point-of-care diagnostic system for effective health care is important for rapid screening of routing biochemical tests. To address this, we have used sol-gel derived process in which Mn induced nano-arrayed structured were developed in TiO2 as a platforms for lab-on-a-chip. Mn doped nanopore TiO2 platforms were prepared by using wet chemistry deposition with the help of metal alkaloxide precursor and assembled with micro-fluidics networks to screen multiple interactions. To demonstrate usefulness of this, enzymatic biocatalyst has been used to determine the specificity of multiple interactions on these platforms. These platforms has been characterized by XRD, XPS, FTIR, SEM, cyclic voltametry to determine structure, surface chemistry and electron transfer characteristics for biosensor applications. Mono-enzyme ChOX, urease and GOX were prepared by immobilizing the separate enzymes onto nanopore TiO2 surfaces modified with Mn doping. The electrochemical detection sensitivity for detection of low concentrations of cholesterol, urea and glucose has been enhanced.