AVS 56th International Symposium & Exhibition
    Applied Surface Science Friday Sessions
       Session AS-FrM

Paper AS-FrM3
Investigation of Internal Structure of Drug Products by TOF-SIMS and CT

Friday, November 13, 2009, 9:00 am, Room C2

Session: Practical Surface Analysis
Presenter: X. Dong, Eli Lilly and Company
Authors: X. Dong, Eli Lilly and Company
C.A.J. Kemp, Eli Lilly and Company
Correspondent: Click to Email
The properties of API and excipients can influence the manufacturing process and the quality attributes of the dosage form. It is known that particle size, shape, and agglomeration of the drug substance and excipients affect flow properties, dissolution behavior, dose uniformity and bioavailability of the formulation. Therefore, there is a key interest in pharmaceutical development to understand how the ingredients of the formulation are blended in the various stages of the production process, as well as how various components distribute in solid dosage form. TOF-SIMS has been applied to provide chemical images for various drug products. Due to the surface sensitivity of this technique, the images could be affected by potential smearing during sample preparation. To better understand the effect of sample preparation, TOF-SIMS images obtained from drug products are compared with micro-CT images, which are obtained non-destructively. In addition, the effects of C60 sputtering on drug molecule and excipeints, as well as on TOF-SIMS images are also investigated.