During the past two decades dramatic advances have been achieved in the performance of organic semiconductor devices. Light emitting diodes, transistors, solar cells, and several other devices can now be fabricated from organic semiconductors and are at various stages of commercialization. This fast-paced progress, which highlights the technological potential of soft materials, is largely a result of advances in our ability to deposit and pattern high quality films. To make this possible, traditional deposition and patterning techniques had to be adapted, and new ones had to be developed. Moreover, the integration of organic semiconductors with biologically-relevant materials, which share some of the processing challenges, promises the development of novel sensors with unmatched capabilities. I will discuss recent advances in the processing of soft materials and the opportunities they have created.