AVS 53rd International Symposium
    Applied Surface Science Wednesday Sessions
       Session AS-WeM

Paper AS-WeM13
The Surface Characterisation of Arrayed Biomaterial Systems

Wednesday, November 15, 2006, 12:00 pm, Room 2005

Session: Molecular Ion Sources and Characterization of Biomaterials
Presenter: A.J. Urquhart, University of Nottingham, UK
Authors: A.J. Urquhart, University of Nottingham, UK
D.G. Anderson, Massachusetts Institute of Technology
M.R. Alexander, University of Nottingham, UK
R. Langer, Massachusetts Institute of Technology
M.C. Davies, University of Nottingham, UK
Correspondent: Click to Email
In recent years the increase in interest in combinatorial materials science, via high throughput synthetic techniques, has attracted considerable interest mainly in the facilitation of rapid discovery and the optimisation of functional polymeric biomaterials.@footnote 1@ Critical to the selection of a biomaterial to a specific clinical application is the relationship between polymer interfacial chemistry and biological response. However, there has been to date few reports addressing the challenge of studying the interfacial chemistry of high throughput arrays with high spatial resolution. Here we report, for the first time, on the surface characterisation of a novel polymer array, comprising of 572 polymer species (each polymer spot being approximately 300 µm in diameter) and fabricated by the Anderson et al. method,@footnote 1@ using X-ray photoelectron spectroscopy (XPS), time of flight secondary ion mass spectroscopy (ToF-SIMS), water contact angle (WCA) and atomic force microscopy (AFM). In order to maximise the information obtained from the large data sets principal component analysis was applied to observe trends between polymer composition and stem cell adhesion/proliferation on the arrays. @FootnoteText@ @footnote 1@ D. G. Anderson, S. Levenberg and R. Langer, Nature Biotechnology, 2004, 22, 863.