AVS 51st International Symposium
    Plasma Science and Technology Friday Sessions
       Session PS+BI-FrM

Paper PS+BI-FrM3
Surface Characterization of Plasma Processed Bio-Functional Micro-Patterned Polymeric Surfaces

Friday, November 19, 2004, 9:00 am, Room 213C

Session: Plasmas in Bioscience
Presenter: A. Valsesia, EU-JRC-IHCP, Italy
Authors: A. Valsesia, EU-JRC-IHCP, Italy
M. Manso, EU-JRC-IHCP, Italy
M. Kormunda, EU-JRC-IHCP, Italy
P. Colpo, EU-JRC-IHCP, Italy
D. Gilliland, EU-JRC-IHCP, Italy
G. Ceccone, EU-JRC-IHCP, Italy
F. Rossi, EU-JRC-IHCP, Italy
Correspondent: Click to Email
The functionalization of the material surfaces is one of the major requirements for the control of the biological response and for the improvement of the biocompatibility. Among the functionalization techniques, PE-CVD is of high importance since the control of the film properties is achieved by an accurate modulation of the plasma processing parameters. PE-CVD allows the synthesis of a wide spectrum of bio-functional polymers: acid/base fouling surfaces (PAA, PAL) and super-hydrophilic anti-fouling surfaces (PEG, PEG-like coatings). Moreover the combination of plasma deposition and plasma etching techniques allows the formation of micro and nano-patterned surfaces with contrasted functionalities. In this work we have studied the plasma deposition of PAA (COOH functional), PAL (NH2 functional) and PEG-like (anti-fouling) layers. The chemical surface characterization of the films has been performed by XPS and TOF-SIMS and the surface free energies components have been calculated by Contact Angle in static and dynamic mode. QCM provided the evaluation of the mechanical stability of the samples in buffer solutions as well as the calculation of the bio-activity of the surfaces in proteins absorption experiments. The surface topography of the samples has been investigated by AFM. The micro-patterned surfaces have been characterized by TOF-SIMS and XPS in imaging mode, revealing the capability of the plasma processing techniques to produce chemically contrasted micrometric motives. The bio-response (protein absorption and cell adhesion) of the micro-patterned samples is under study.