AVS 50th International Symposium
    Biomaterial Interfaces Wednesday Sessions
       Session BI-WeM

Paper BI-WeM7
Nanodevices Integrating Biomolecular Motors: Design Strategies and Applications

Wednesday, November 5, 2003, 10:20 am, Room 317

Session: Bionanoscale Analysis: Theory to Experiment
Presenter: H. Hess, University of Washington
Authors: H. Hess, University of Washington
J. Clemmens, University of Washington
C. Matzke, Sandia National Laboratories
G.D. Bachand, Sandia National Laboratories
B.C. Bunker, Sandia National Laboratories
V. Vogel, University of Washington
Correspondent: Click to Email
Biomolecular motors are at present the engines of choice for nanodevices.@footnote 1,2@ Their small size, high efficiency, and functional integration allow the construction of hybrid devices, which demonstrate the promise of engineering at the nanoscale. We will discuss the tools employed in designing these devices, which include surface patterning, microfabrication, and genetic engineering. Our recent results@footnote 3@ show that these tools have to be employed in concert, in order to achieve outstanding results. For example, controlled placement of motor proteins on a surface requires non-fouling regions of high quality, as well as fine-tuning of the adsorption properties of the motors by genetic engineering. The design process in general requires an in-depth understanding of the motor properties as well as the properties of the filaments the motor proteins bind to (e.g. microtubules). New measurements aim at determining these properties. We will also present an overview of the applications studied by us, ranging from molecular shuttles@footnote 4,5@ to surface imaging @footnote 6@ and force measurements.@footnote 7@ @FootnoteText@@footnote 1@ H. Hess and V. Vogel, Reviews in Molecular Biotechnology, 82, 67-85 (2001)@footnote 2@ H. Hess, G. Bachand, and V. Vogel in: Encyclopedia of Nanoscience and Nanotechnology. Edited by James A. Schwarz, Cristian Contescu, and Karol Putyera (Marcel Dekker, New York, in print)@footnote 3@ J. Clemmens, H. Hess, J. Howard, V. Vogel, Langmuir, 19, 1738-1744 (2003)@footnote 4@ H. Hess, J. Clemmens, D. Qin, J. Howard, and V. Vogel, Nano Letters, 1 (5), 235-239 (2001)@footnote 5@ H. Hess, J. Clemmens, C. M. Matzke, G. D. Bachand, B. C. Bunker, and V. Vogel, Appl. Phys. A, A 75, 309-313 (2002)@footnote 6@ H. Hess, J. Clemmens, J. Howard, and V. Vogel, Nano Letters, 2 (2), 113-116 (2002)@footnote 7@ H. Hess, J. Howard, and V. Vogel, Nano Letters, 2(10), 1113-5 (2002).