AVS 50th International Symposium
    Applied Surface Science Tuesday Sessions
       Session AS+BI-TuA

Paper AS+BI-TuA10
Utilization of Polyatomic Primary Ion Sources for Analysis of Drug Delivery Systems by Secondary Ion Mass Spectrometry (SIMS)

Tuesday, November 4, 2003, 5:00 pm, Room 324/325

Session: Biomaterials Characterization
Presenter: C.M. Mahoney, National Institute of Standards and Technology
Authors: C.M. Mahoney, National Institute of Standards and Technology
G. Gillen, National Institute of Standards and Technology
Correspondent: Click to Email
The utilization of cluster primary ion beams in SIMS has become very popular in the last decade due to the increased secondary ion yields as compared to monoatomic sources.@footnote 1-4@ In particular the analysis of organic materials has gained considerable interest as these cluster primary ion beam sources (in particular SF@sub 5@@super +@) have resulted in the enhancement of characteristic molecular secondary ion yields and have decreased the beam induced damage.@footnote 4@ Furthermore, the increased sputter rate with decreased beam damage has allowed for depth profiling in organic films and polymers for the first time with limited success.@footnote 4@ Here we explore the applicability of cluster SIMS in the analysis of various materials utilized in drug delivery. The effects of SF@sub 5@@super +@ bombardment on molecular secondary ion yields will be explored in various biodegradable polymers (polylactic acid, polyglycolic acid and polycaprolactone) as well as several model drugs (theophylline, 4'-hydroxyacetanilide, amyloid probe). The enhancement in the sensitivity will then be applied to imaging applications where it will be shown that imaging with SF@sub 5@@super +@ enhances the signal intensity as compared to Ar or Cs primary ions resulting in more sensative imaging capabilities. This will be useful in many systems where the concentration of drug is very low (e.g. biological samples, ppb-ppm range). Dynamic SIMS analysis (utilizing SF@sub 5@@super +@) of a series of polylactic acid films doped with varying concentrations of 4'-hydroxyacetanilide will also be discussed. @FootnoteText@ @footnote 1@ Kotter, F.; Benninghoven, A. Applied Surface Science 133 (1998) 47.@footnote 2@ Appelhans, A.D.; Delmore, J. Anal. Chem. 61 (1989) 1087.@footnote 3@ Gillen, G.; King, R.L.; Chmara, F. J. Vac. Sci. Technol. A 17(3) (1999) 845.@footnote 4@ Gillen, G.; Roberson, S.; Rapid Commun. Mass Spectrom. 12 (1998) 1303.