Traditional surgery for many medical problems, including gallstones, endometriosis, and various cancers, usually requires long, deep incisions and a lengthy recovery period. Minimally invasive surgery, also known as "keyhole" or "band-aid" surgery, has been used for several years as an alternative to traditional "open" surgery. Minimally invasive procedures for both diagnostics and therapeutics have generated much attention from clinicians, patients, and healthcare administrators for their ability to reduce patient pain, scarring, and hospital stays. Current tools for minimally invasive procedures typically tend to operate as mechanical appendages of the clinician, but with absence to touch-and-feel sensations and only limited vision. The ability of MEMS technology to develop miniature, low-cost, and sophisticated transducers is particularly attractive for the development of smart surgical tools that enhance clinical efficacy. The talk will present an overview of current and upcoming applications of MEMS technology in cardiology, neurology, and orthopedics that are under development at The Cleveland Clinic Foundation and other institutions. Device examples will include pressure sensors, accelerometers, strain gauges, flow meters, valves, pumps, imaging transducers, drug delivery systems, and cutting tools.