AVS 47th International Symposium
    Biomaterial Interfaces Wednesday Sessions
       Session BI-WeP

Paper BI-WeP1
Hydroxy-containing Amino Acid Derivatives Adsorbed on Gold

Wednesday, October 4, 2000, 11:00 am, Room Exhibit Hall C & D

Session: Poster Session
Presenter: A. Borgh, Linköping University, Sweden
Authors: J. Svensson, Linköping University, Sweden
A. Borgh, Linköping University, Sweden
K. Uvdal, Linköping University, Sweden
B. Liedberg, Linköping University, Sweden
P. Konradsson, Linköping University, Sweden
Correspondent: Click to Email
More than 10% of the proteins in the body are involved in phosphorylations. As a phosphate group is attached to serine, threonine or tyrosine, the protein changes its conformation. This change in conformation is often ascribed to neutralization of charges, i.e. by electrostatic interactions. The attachment also effects the surrounding water structure and this change in water structure could be the reason to conformational changes. We describe here the preparation of a series of model surfaces, based on self-assembly on gold, in order to study the surrounding water structure. Surface characterization is performed using infrared reflection-absorption spectroscopy (IRAS), ellipsometry, contact angle goniometry and X-ray photoelectron spectroscopy. The molecules are found to form highly ordered monolayers and the thicknesses of the monolayers are in good agreement with expected values from space filling models. Water structure studies are performed using IRAS and temperature programmed desorption.