| AVS 62nd International Symposium & Exhibition | |
| Biomaterials Plenary Session | Sunday Sessions |
| Session BP-SuA |
| Session: | Biomaterials Plenary Session |
| Presenter: | Phillip Messersmith, University of California at Berkeley |
| Authors: | T. Sileika, Northwestern University D. Barrett, Northwestern University P.B. Messersmith, University of California at Berkeley |
| Correspondent: | Click to Email |
Polyphenols are found in both plant and animal tissues, where they serve a variety of functions including mechanical adhesion, structural support, pigmentation, radiation protection, and chemical defense. In animals, polyphenols are found in the adhesive proteins secreted by sessile marine organisms. In mussels, the adhesive proteins are known to contain high levels of 3,4-dihydroxy-L-alanine (DOPA), an amino acid that is believed to be important in adhesion to substrates. In plants, polyphenolic compounds containing benzenediol (catechol) and/or benzenetriol (gallol) functional groups are widely distributed secondary metabolites with a variety of biochemical and physical functions. Consumption of foods and beverages rich in polyphenols are claimed to be beneficial to one’s health.
This talk will focus on selected biological polyphenols that are rich in catechol or gallol functional groups, with the goal of developing novel materials inspired by biological polyphenols. In the case of mussel-inspired biomaterials, we focus on understanding the molecular aspects of mussel adhesion, and in developing biomimetic polymer hydrogels and coatings from synthetic catechol containing polymers[1-4]. These biologically inspired materials have a variety of functional uses, including tissue repair, drug delivery and antifouling coatings. In the case of plant polyphenols, we as well as others have recently discovered that gallol-rich compounds found in tea, coffee beans, cacao beans and other plant tissues form thin adherent polymerized films on substrates by simple immersion [5,6]. Deposition is facile on a variety of solid, porous and nanoparticulate substrates composed of metals, ceramics and polymers. In addition to possessing inherent antibacterial and antioxidant properties, the nanoscale polyphenol films serve as versatile ‘primers’ facilitating secondary modifications of the primer coating such as metallization and covalent grafting of biomolecules and synthetic polymers. Such secondary modifications can be exploited for a variety of practical applications, including antibacterial, antioxidant and fouling resistant coatings on medical devices, metal deposition, plasmonic tuning and surface functionalization of nanoparticles.
References
1. Lee, B., et al., Ann. Rev. Mater. Res., 2011. 41: 99.
2. Lee, H., et al., Science, 2007. 318: 426.
3. Lee, H., B. Lee, and P.B. Messersmith, Nature, 2007. 448: 338.
4. Lee, H., N.F. Scherer, and P.B. Messersmith, Proc. Nat. Acad. Sci., 2006. 103: 12999.
5. H. Ejima, et al., Science, 2013. 341: 154.
6. Sileika, T.S., et al., Angew Chem Int Ed Engl, 2013. 52: 10766.