| AVS 62nd International Symposium & Exhibition | |
| Applied Surface Science | Thursday Sessions |
| Session AS-ThM |
| Session: | Practical Surface Analysis III: Multiple-technique Problem-solving and Structure-property Correlations |
| Presenter: | Xia Dong, Eli Lilly and Company |
| Authors: | X. Dong, Eli Lilly and Company Z. Xiao, Eli Lilly and Company C.A.J. Kemp, Eli Lilly and Company G.H. Shi, Eli Lilly and Company |
| Correspondent: | Click to Email |
Time-based glide-force changes in pre-filled syringes built into autoinjector systems can lead to negative patient experience issues and dose accuracy problems. The long term performance of prefilled syringe systems is examined during stability testing study when monoclonal antibody solutions are stored at various temperatures for given time periods. Multiple parameters including lubricant amount, lubricant distribution, and surface chemistry contribute to friction between the plunger and barrel and consequently the glide force. Therefore, it is important to understand the impact of storage conditions on lubricant characteristics and surface properties so that the desirable long term performance can be achieved.
In the current study, a monoclonal antibody solution was filled in glass syringes coated with silicone lubricant. Increased glide forces were observed from syringes stored at 25 oC, comparing to those stored at 5 oC. Multiple analytical techniques, including ellipsometry, ICP-OES, contact angle, XPS and TOF-SIMS were utilized to characterize lubricant and surface properties of syringe interior surfaces to understand the root cause of undesirable glide force changes.