AVS 55th International Symposium & Exhibition
    Nanometer-scale Science and Technology Wednesday Sessions
       Session NS+NC-WeM

Paper NS+NC-WeM11
Characterization of Graphitic Coated Magnetic Nanoparticles used in Cancer Therapy

Wednesday, October 22, 2008, 11:20 am, Room 311

Session: Characterization and Imaging of Nanostructures
Presenter: S. Trigwell, ASRC Aerospace
Authors: S. Trigwell, ASRC Aerospace
A.S. Biris, University of Arkansas at Little Rock
Y. Xu, University of Arkansas at Little Rock
Z. Li, University of Arkansas at Little Rock
M. Mahmood, University of Arkansas at Little Rock
T.S. Nunney, Thermo Fisher Scientific, UK
Correspondent: Click to Email

Graphitic carbon coated ferromagnetic nanoparticles of Co and Co/Fe with diameters of approximately 7 nm and cubic crystalline structures were synthesized by catalytic chemical vapor deposition (CCVD). X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis indicated that the metallic nanostructures inside the carbon shells were preserved in the metallic state and were not oxidized, which made them excellent candidates for electromagnetic radiation absorbers for biological thermal applications. Confocal microscope images revealed effective penetrations of the nanoparticles through plasmatic membranes into cultured HeLa cancerous cells both in the cytoplasm as well as the nucleus. Low RF radiation of 350 kHz triggered the cell death, a process that was application time and nanoparticle concentration dependant. Compared to nanostructures such as single wall carbon nanotubes, magnetic nanoparticles demonstrated higher specificity for RF absorption and heating.