Invited Paper MI+BI-ThA6
Multifunctional Ferromagnetic Disks for Life Sciences Applications

Thursday, October 25, 2018, 4:00 pm, Room 203A

The impact of modern nanomaterials and engineered architectures on biological modulation, bioanalytical techniques, and healthcare technologies can hardly be overestimated. Magnetic nanomaterials are attractive for life sciences applications because they can be detected and operated remotely, biological barriers-free, using external magnetic field. Using top-down micro-/nano-fabrication techniques allows for production of monodisperse magnetic particles of virtually any composition and shape, with tunable magnetic properties. Such particles have been exploited as multi-spectral MRI contrast enhancement labels, for in vitro detection of molecular markers and cell sorting. This talk will summarize successful applications of lithographically defined disk-shaped particles composed of ferromagnetic Fe₂₀Ni₈₀ permalloy core for biomedical applications in both low- and high frequency magnetic field regimes as mediators of biological mechanotrasduction, as delivery vehicles, contrast agents and ultrasensitive detection labels. Advanced synchrotron imaging was used to visualize interaction of engineered nanomagnetic hybrids with living systems and study their chemical stability at subcellular, cellular and 3D multicellular levels.

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