| AVS 65th International Symposium & Exhibition | |
| Biomaterial Interfaces Division | Thursday Sessions |
| Session BI-ThA |
| Session: | Biolubrication and Wear / Women in Bio-surface Science |
| Presenter: | Eva Bittrich, Leibniz-Institut für Polymerforschung Dresden e.V., Germany |
| Authors: | E. Bittrich, Leibniz-Institut für Polymerforschung Dresden e.V., Germany C. Naas, Leibniz-Institut für Polymerforschung Dresden e.V., Germany F. Mele, Leibniz-Institut für Polymerforschung Dresden e.V. and Polytechnic University of Turin, Italy A. Münch, Leibniz-Institut für Polymerforschung Dresden e.V., Germany P. Uhlmann, Leibniz-Institut für Polymerforschung Dresden e.V.,Germany D. Appelhans, Leibniz-Institut für Polymerforschung Dresden e.V., Germany K.-J. Eichhorn, Leibniz-Institut für Polymerforschung Dresden e.V., Germany B. Voit, Leibniz-Institut für Polymerforschung Dresden e.V., Germany |
| Correspondent: | Click to Email |
Controlling and understanding the interaction behavior of biomolecules with polymer surfaces is one key aspect for the design of new biomaterials. Thin hydrogel coatings offer a huge variety of possibilities to tune physical and chemical surface properties and to create functional biocompatible interfaces supported on a substrate material. Among polymer architectures studied for biocompatible systems are dendritically structured polycations decorated with oligosaccharide shell [1, 2], and zwitterionic copolymers based on phosphorylcholine groups [3]. We prepared two types of thin hydrogel films: 1) based on dendritic polymer core-shell nanoparticles of hyperbranched poly (ethylene imine) (PEI) with maltose shell and 2) based on the statistical copolymer poly[(2-methacryloyloxyethyl phosphorylcholine)-co-(glycidyl methacrylate)] (MPC-co-GMA). For both surface types swelling and the interaction with selected biomolecules from small drug molecules to proteins and phospholipids was analyzed quantitatively by in-situ spectroscopic ellipsometry and quartz crystal microbalance with dissipation monitoring. The adsorbed amount of biomolecules was correlated to changes in hydration, thickness and viscoelastic properties of the films to obtain new insights into the specific interaction processes.
References
[1] M. Warenda, K.-J. Eichhorn, B. Voit, D. Appelhans et Al., Macromol. Rapid Commun. 33 (2012) 1466.
[2] D. Wrobel, D. Appelhans, B. Voit et Al., Colloid. Surf. B: Biointerfaces 152 (2017) 18.
[3] A. S. Münch, K.-J. Eichhorn, P. Uhlmann et Al., J. Mater. Chem. B 6 (2018) 830.