AVS 64th International Symposium & Exhibition
    Exhibitor Technology Spotlight Workshops Tuesday Sessions
       Session EW-TuL

Paper EW-TuL3
Application of X-ray Photoelectron Spectroscopy for the Characterisation of Biomaterials

Tuesday, October 31, 2017, 1:00 pm, Room West Hall

Session: Exhibitor Technology Spotlight
Presenter: Jonathan Counsell, Kratos Analytical Limited, UK
Authors: C. Moffitt, Kratos Analytical Ltd
D. Surman, Kratos Analytical Limited
S.J. Coultas, Kratos Analytical Limited, UK
J.D.P. Counsell, Kratos Analytical Limited, UK
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The Kratos AXIS series of photoelectron spectrometers are now widely applied to the characterisation of surfaces of biological interest. With its high energy resolution and excellent sensitivity at selected areas, XPS is routinely used to determine the surface chemistry of materials which interact with the native-tissue, organ or function in a body. Both the AXIS Supra and AXIS Nova utilize large sample holders and, when combined with the standard automated sample transfer capability, provides the ability for high sample throughput. These strengths are demonstrated in the XPS characterisation of printed micro-patterned co-polymer arrays leading to the discovery of novel biopolymers. The high spatial resolution imaging capability of the AXIS spectrometers is also used to probe the lateral distribution of surface chemistry of these co-polymer array samples. The recent development of the gas cluster ion source (GCIS) for depth profiling ‘soft’ materials means that XPS is no longer limited to simple surface analysis. The characterisation of the sub-surface and bulk biomaterial properties is now a reality and is demonstrated in the depth profiling of drug eluting bioresorbable stents. The efficacy of these stents is dependent on the drug distribution through the coating which is measured during a GCIS depth profile. In this presentation we will demonstrate the capabilities of the latest Kratos X-ray photoelectron spectrometers lateral resolution, depth distribution of elemental and chemical states, and detection sensitivity through the characterisation of biomaterials.