| AVS 63rd International Symposium & Exhibition | |
| Plasma Processing for Biomedical Applications Focus Topic | Monday Sessions |
| Session PB+BI+PS-MoA |
| Session: | Plasma Processing of Biomaterials |
| Presenter: | Farzaneh Arefi-Khonsari, l'université Pierre et Marie Curie, France |
| Authors: | F. Arefi-Khonsari, l'université Pierre et Marie Curie, France A. Baitukha, Sorbonne Universités, UPMC, France J. Pulpytel, Sorbonne Universités, UPMC, France A. Valinataj Omran, Sorbonne Universités, UPMC, France |
| Correspondent: | Click to Email |
In this talk, different nonequilibrium atmospheric pressure plasmas used for biomedical applications such as planar DBD, single and double barrier DBD plasma jets, and transported discharges in tubes will be discussed. Indeed in the case of the latter, deposition and surface treatment, by means of a He cold transported discharge in tubes as long as 200 cm and tube inner diameters ranging from 1 to 20 mm, can present a great potential for surface modification of polymers used as biomaterials. We have, as well as several research groups, succeeded to retain the precursor moieties to obtain PEG like polymers which present interesting antifouling properties by using planar DBD and jets. However for particular plasma applications such as making a Drug Delivery System (DDS) based on several polymer or copolymer layers, encapsulating the drug, it is more reasonable to use a low pressure plasma which can give rise to dense crosslinked barrier films. The latter are less flexible and develop microcracks due to swelling and curvature of the host biocompatible and biodegradable substrate. In order to obtain good cohesive coatings with excellent barrier and mechanical properties, it is very important to deposit layers presenting a vertical chemical gradient, where stress is gradually distributed over the rigid and flexible zones of the DDS, which is more easily deposited in low pressure plasmas. Our recent results in copolymerizing amphiphilic precursors for the use of cell adhesive or nonadhesive surfaces will be presented. Such copolymers can be also used as biodegradable multi-layer copolymers for drug delivery applications. Human ovarian carcinoma cell lines (NIH:OVCAR‑3) were used for in vitro measurements of cell interactions with the surface of fabricated DDS. Proposed model of DDS on collagen films prevents migration, adhesion and growth of cancer cells on its surface, and by tuning the thickness of the dense barrier films, encapsulating the drug, it is possible to control the drug release kinetics and to improve the therapeutic effect. In vivo experiments were carried out by injecting OVCAR3 cells in mice lymph nodes to develop a tumor, followed by implantation of the DDS membranes to evaluate the feasibility of the proposed model.