| AVS 63rd International Symposium & Exhibition | |
| Biomaterial Interfaces | Tuesday Sessions |
| Session BI+AS+SA-TuA |
| Session: | Biophysics and Characterization of Biological and Biomaterial Surfaces |
| Presenter: | Katharina Maniura, Empa, Swiss Federal Laboratories for Materials Science and Technology, Switzerland |
| Correspondent: | Click to Email |
Generally, the majority of biomaterials are tested using in vitro cell monocultures, however, this approach neglects possible synergistic interactions between different cell types and paracrine signalling mediating the tissue-specific response to a material.
Immediately upon implantation, medical implants get exposed to the patient’s blood and this initiates the first phase of wound healing and subsequent cell recruitment and response deciding about material integration or non-integration.
We have established that blood pre-incubation of implant surfaces mimics a more physiological situation, providing a more predictive in vitro model for the evaluation of novel implant surfaces.
Similarly, many promising antimicrobial materials failed to make the translation from bench to bedside, partially due to insufficient in vitro biofilm models used for predicting the long-term in vivo antimicrobial and anti-biofilm activity. For the evaluation of novel surfaces the actual forseen implantation location and its biological environment need be considered to design a more predictive bacterial study with conditions mimicking the in vivo situation.