Invited Paper 2D+TF-WeM3
Scalabale Production of Molybdenum Disulfide-based Biosensors

Wednesday, November 9, 2016, 8:40 am, Room 103B

We demonstrate biosensor arrays based on CVD-grown molybdenum disulfide (MoS₂) field effect transistors (FETs) coupled to a computationally-redesigned soluble variant of the μ-opioid receptor (MOR). By transferring dense films of monolayer MoS₂ crystals onto prefabricated electrode arrays, we obtain clean, high-quality FETs that allow reproducible protein attachment. The yield of MoS₂ FETs and biosensors exceeds 95%, with average mobility of 2.0 cm²V^-1s^-1 (36 cm²V^-1s^-1) under ambient (in vacuum). An atomic length linker chemistry enables target binding very close to the MoS₂ surface to maximize sensitivity. The biosensor calibration curve for a synthetic opioid peptide target indicates binding affinity that matches values determined using traditional techniques and a limit of detection ~ 3 nM. The combination of scalable array fabrication and rapid readout enabled by MoS₂ transistors offer the prospect of a solid-state drug testing platform for rapid readout of the interactions between novel drugs and their intended protein targets.