| AVS 62nd International Symposium & Exhibition | |
| Biomaterials Plenary Session | Sunday Sessions |
| Session BP-SuA |
| Session: | Biomaterials Plenary Session |
| Presenter: | Suzie Pun, University of Washington |
| Authors: | L. Chan, University of Washington M. Cieslewicz, University of Washington G. Liu, University of Washington B. Livesay, University of Washington C. Ngambenjawong, University of Washington S. Pun, University of Washington S. Salipante, University of Washington N. White, University of Washington |
| Correspondent: | Click to Email |
Peptide phage display is a powerful tool for identifying novel targeting ligands. We have recently used peptide phage display combined with next generation sequencing for efficient identification of targeting ligands. I will first present our discovery of a peptide that preferentially binds to “anti-inflammatory” (M2) macrophage. This peptide can be used to target tumor-associated, M2-like macrophage in the tumor microenvironment. Multivalent display of this peptide using peptide-based copolymers significantly increases binding avidity of the polymer with M2 cells. In a second example, a fibrin-binding peptide identified by the Caravan Group (Massachusetts General Hospital) using peptide phage display was incorporated into brush-shaped, peptide-based copolymers. These polymers were synthesized by controlled radical polymerization with well-defined compositions and molecular weights and possess the biological functions contributed by their peptide components. The resulting polymer incorporates into forming clots and increases clot strength while improving resistance to clot lysis. Delivery of this polymer to a rat model of trauma significantly improved survival compared to controls.