The capability to assemble two-dimensional (2D) materials into layered heterogeneous structures presents an exciting new opportunity in materials design. For example, encapsulating graphene with hexagonal BN yields enhanced transport properties with reduced environmental sensitivity, and allows for complex band structure engineering. This has enabled graphene to be exploited as a model experimental platform to study a wide range of fundamental physics arising both from conventional single-particle considerations, as well as more exotic emergent behaviour in the strongly interacting regime. Graphene however represents just one of a larger subset of layered materials, which are now receiving growing attention due to their diverse array of intrinsic properties. The opportunity to “mix and match” these disparate crystals to realize fundamentally new hybrid material properties provides an almost unbounded new direction as we look for quantum materials beyond graphene. In this talk I will outline some of the fundamental questions, and technical challenges facing these efforts and highlight some of our recent innovations in this direction. Implications for the development of new device geometries and scientific pursuits will be discussed.