| AVS 61st International Symposium & Exhibition | |
| Surface Science | Wednesday Sessions |
| Session SS-WeA |
| Session: | Chirality and Enantioselectivity on Surfaces |
| Presenter: | Nisha Shukla, Carnegie Mellon University |
| Authors: | N. Shukla, Carnegie Mellon University N. Ondeck, Carnegie Mellon University N. Khosla, Carnegie Mellon University A.J. Gellman, Carnegie Mellon University |
| Correspondent: | Click to Email |
Au nanoparticles modified with enantiomerically pure D- or L-cysteine have been shown to serve as enantioselective adsorbents of R- and S-propylene oxide [1]. A simple adsorption model and accompanying experimental protocol have been developed to enable optical rotation measurements to be analyzed for quantitative determination of the ratios of the enantiospecific adsorption equilibrium constants of chiral species on the surfaces of chiral nanoparticles, (KSL ⁄(KSD )=(KRD)⁄(KRL). This analysis is robust in the sense that it obviates the need to measure the absolute surface area of the absorbent nanoparticles, a quantity that is somewhat difficult to obtain accurately. This analysis has been applied to optical rotation data obtained from solutions of R- and S-propylene oxide, in varying concentration ratios, with D- and L-cysteine coated Au nanoparticles, in varying concentration ratios [2].
[1] N. Shukla, M.A. Bartel, A.J. Gellman “Enantioselective separation on chiral Au nanoparticles” Journal of the American Chemical Society, 132(25), (2010), 8575–858.
[2] N. Shukla, N. Ondeck, A.J. Gellman “Quantitation of Enantiospecific Adsorption on Chiral Nanoparticles” Surface Science, (accepted-2014).