| AVS 61st International Symposium & Exhibition | |
| Applied Surface Science | Tuesday Sessions |
| Session AS+MC+SS-TuA |
| Session: | Analysis of Modified Surfaces |
| Presenter: | Ich Tran, Lawrence Livermore National Laboratory |
| Authors: | I.C. Tran, Lawrence Livermore National Laboratory T.W. van Buuren, Lawrence Livermore National Laboratory T.M. Willey, Lawrence Livermore National Laboratory J.R.I. Lee, Lawrence Livermore National Laboratory M. Bagge-Hansen, Lawrence Livermore National Laboratory A. Noy, Lawrence Livermore National Laboratory R. Tunuguntla, Lawrence Livermore National Laboratory K. Kim, Lawrence Livermore National Laboratory |
| Correspondent: | Click to Email |
Development in nanoscale engineering has enabled bioelectronics that can mimic and/or interact with the biological systems. Lipid bilayer-functionalized Si nanowires are considered as a promising candidate for the construction of bio-nanoelectronic devices. These biomimetic lipid bilayers serve as a general host matrix for bio-functional components such as membrane proteins. Though meaningful technological advancements have been made, critical questions still remain, in particular on structural characteristics of lipid bilayers at the interface with inorganic nanomaterials. Small-angle and wide-angle x-ray scattering (SAXS/WAXS) techniques are used to investigate self-organizations of dioleoyl-phosphatidylcholine (DOPC) lipid bilayers on Si nanowires. Critical structural parameters of the lipid bilayers (lamellarity, bilayer thickness and packing order of lipid molecules) are obtained through analyzing SAXS-derived Electron Density Profile (EDP). A decrease in bilayer thickness and a packing disorder of the lipid head groups in adjacent to supported Si nanowires have been observed upon coating on Si nanowires. Furthermore, effects on the packing order of lipid hydrocarbon tails induced by the incorporations of proteins or carbon nanotubes into lipid bilayers (served as natural or artificial ion channels, respectively) have been identified and characterized. The results shed light on a number of unresolved questions that are crucial for the comprehensive understanding this class of materials.
This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.