This talk will cover work in my laboratory over the past decade on the self-assembly of genetically encoded stimulus responsive elastin-like polypeptides (ELPs). We have exploited ELPs to create stimulus responsive nanostructures via three approaches. In the first approach, we have designed diblock ELPs with two ELP blocks with different hydrophobicity’s that self-assemble into spherical micelles with an increase in temperature about the critical micellization temperature of the diblock polymer. Building on this architecture, we have incorporated histidine residues in the hydrophobic block to create a diblock ELP that self-assembles into spherical micelles with an increase in temperature, while a small drop in pH from 7.4 to 6.4 leads to micelle disassembly. In a second –chemical attachment triggered self-assembly– approach, we have shown that the attachment of multiple copies of small molecule hydrophobes to the multiple cysteine (C) residues of an ELP with the sequence (VPGXG)n(CGG)8 can drive their self-assembly into spherical micelles. In a third approach, we replace the Cys (C) with W, Y, or F, and find that oddly, this leads to the formation of stimulus responsive worms and vesicles depending on the specific residue. These are the first examples of stimulus responsive worms and vesicles in peptide polymers.