AVS 60th International Symposium and Exhibition
    Biomaterial Interfaces Thursday Sessions
       Session BI+AS+BA+NS+SS-ThA

Paper BI+AS+BA+NS+SS-ThA1
The Protein Resistance Properties of Hydroxy- and Methoxy-terminated Oligo(ethylene oxide) (OEO) Self-Assembled Monolayers (SAMs) to Membrane Proteins

Thursday, October 31, 2013, 2:00 pm, Room 102 B

Session: Biomolecules at Interfaces
Presenter: M. Walker, National Institute of Standards and Technology (NIST)
Authors: M. Walker, National Institute of Standards and Technology (NIST)
A. Vaish, National Institute of Standards and Technology (NIST) and Institute of Bioscience and Biotechnology Research
D. Vanderah, National Institute of Standards and Technology (NIST) and Institute of Bioscience and Biotechnology Research
Correspondent: Click to Email

Spectroscopic ellipsometry was used to evaluate the resistance to protein adsorption of self-assembled monolayers (SAMs) of HS(CH2)3O(CH2CH2O)6M and [HS(CH2)3]2CHO-(CH2CH2O)6M, where M = CH3 or H, on Au. The SAMs were exposed to fibrinogen, a soluble protein frequently used to evaluate surface protein resistance properties, and rhodopsin, an integral membrane protein. We show that the that the nature of the oligo(ethylene oxide) end group governs the extent of protein adsorption resistance of OEO SAMS to integral membrane proteins.