AVS 60th International Symposium and Exhibition
    Biomolecules at Aqueous Interfaces Focus Topic Monday Sessions
       Session BA+AI+AS+BI+IS+NL-MoM

Invited Paper BA+AI+AS+BI+IS+NL-MoM3
Probing Nanoparticle-lipid Bilayer Interactions with Nonlinear Optics

Monday, October 28, 2013, 9:00 am, Room 203 A

Session: Biomolecules at Aqueous Interfaces
Presenter: F. Geiger, Northwestern University
Correspondent: Click to Email
The interaction of engineered nanoparticles with biological membranes is an important and necessary first step for cellular uptake. Here, we probe this interaction by applying second harmonic and vibrational sum frequency generation as well as the Eisenthal chi(3) method to supported bilayer-based model systems as well as shewanella and daphnia magna, chosen as important biological endpoints, exposed to 4 nm sized noble metal nanoparticles surrounded by negatively and positively charged ligands. Our studies are complemented by a plethora of supporting experiments based on quartz crystal microbalance, zeta potential, and related experiments. We find that Coulomb's law dictates much of the interactions in the particular systems studied here.