AVS 59th Annual International Symposium and Exhibition
    Biomaterial Interfaces Tuesday Sessions
       Session BI-TuP

Paper BI-TuP9
Stability and Dispersion Characterstics of Ceria Nanoparticles in Biological Media

Tuesday, October 30, 2012, 6:00 pm, Room Central Hall

Session: Biomaterial Interfaces Poster Session
Presenter: P. Munusamy, Pacific Northwest National Laboratory
Authors: P. Munusamy, Pacific Northwest National Laboratory
T. Suntharampillai, Pacific Northwest National Laboratory
D.R. Baer, Pacific Northwest National Laboratory
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Although nanoparticles have wide variety of biomedical applications, the characteristics that produce beneficial or toxic effects are not well understood. Some ceria nanoparticles have gained high visibility for their redox active properties which appear to serve as free radical scavengers. Toxicity measurements of various types and sizes of ceria nanoparticles tested with a variety of in-vitro and in-vivo studies have many apparent inconsistencies. To accurately evaluate in-vitro and in-vivo testing results it is important to understanding the properties and behaviors of the ceria particles in the media in which the tests are conducted. In this work, ceria nanoparticles prepared by thermal hydrolysis process are used as a model nanoparticle to study there stability and dispersion characteristics. The particles behaviors in biological media such as aggregation and sedimentation rates were systematically evaluated by aggregation kinetic analysis and sedimentation studies. As one example, fetal bovine serum (FBS) which consists of multiple proteins components was found to be an effective dispersion agent forming a relatively robust surface layer with 24 hours. Data on mixtures of common biological media solutions show a variety of differing impacts. The type of kinetic data we have collected provides important information regarding behavior of nanoparticles in different dispersion media which valuable in understanding toxicity and other biological impact studies.