| AVS 59th Annual International Symposium and Exhibition | |
| Biomaterial Interfaces | Monday Sessions |
| Session BI-MoM |
| Session: | Surfaces to Control Cell Response |
| Presenter: | B.W. Muir, CSIRO Materials Science and Engineering, Australia |
| Authors: | B.W. Muir, CSIRO Materials Science and Engineering, Australia R. Chen, CSIRO Materials Science and Engineering and The University of Melbourne, Australia G.K. Such, The University of Melbourne, Australia A. Postma, CSIRO Materials Science and Engineering, Australia R.A. Evans, CSIRO Materials Science and Engineering, Australia K.M. McLean, CSIRO Materials Science and Engineering, Australia F. Caruso, The University of Melbourne, Australia |
| Correspondent: | Click to Email |
The development of versatile and robust strategies for the surface modification of multiple classes of materials has proven challenging, with few generalized methods. Many available methods have limitation for widespread use due to the need for specific surface chemistries and/or laborious multistep procedures[1]. A protocol to deposit brominated plasma polymer (Brpp) thin films on a variety of substrate surfaces (silicon wafers, glass, gold, Teflon) has been developed. These coatings are highly adherent and exhibit good stability in aqueous, biphasic and autoclaving conditions. The Brpp coating was found to be a useful platform for secondary reactions leading to surfaces with specific chemical properties. Following nucleophilic exchange, azide functionalized surfaces were developed and the copper catalysed azide alkyne cycloaddition (CuAAC) reaction[2]; a paradigm of click chemistry, was successful in immobilizing various acetylenes. A particular highlight is the patterning of cells via selective surface functionalisation of PEG-alkyne using a photomask.[3] This is the first known example of CuAAC reactions on pp thin films. A detailed physicochemical characterisation study of these films will also be presented.
[1] aH. Lee, S. M. Dellatore, W. M. Miller, P. B. Messersmith, Science 2007, 318, 426-430; bD. Y. Ryu, K. Shin, E. Drockenmuller, C. J. Hawker, T. P. Russell, Science 2005, 308, 236-239.
[2] R. A. Evans, Australian Journal of Chemistry 2007, 60, 384-395.
[3] Chen, R. T.; Marchesan, S.; Evans, R. A.; Styan, K. E.; Such, G. K.; Postma, A.; McLean, K. M.; Muir, B. W*.; Caruso, F., Biomacromolecules 2012, 13, (3), 889-895.