| AVS 58th Annual International Symposium and Exhibition | |
| Biomaterial Interfaces Division | Thursday Sessions |
| Session BI-ThP |
| Session: | Biomaterial Interfaces Poster Session |
| Presenter: | Stella North, Naval Research Laboratory (NRL) |
| Authors: | E.H. Lock, Naval Research Laboratory (NRL) S.H. North, Naval Research Laboratory (NRL) S.G. Walton, Naval Research Laboratory (NRL) C.R. Taitt, Naval Research Laboratory (NRL) |
| Correspondent: | Click to Email |
The ability to predict and manipulate biomolecule behavior at the biointerface determines the success of biomaterials in applications ranging from biosensing to medical devices and therapeutic products. However, precise biointerface engineering will remain elusive until the roles of physical and chemical properties of surfaces on abiotic and biotic interfacial interactions are well understood. We have shown that plasma treatment of polymers generates chemically reactive surfaces for successful silanization and biomolecule immobilization [1, 2]. The focus of this work is to investigate the influences of surface chemistry and surface morphology on biomolecule attachment. We fine-tune our plasma system to favor the production of specific functional groups that promote subsequent biomolecule attachment. The effects of surface morphology on biomolecule immobilization are also assessed. Plasma diagnostics and modeling allows us to elucidate the effects of plasma parameters (plasma density, electron temperature and the resulting kinetic ion energy) on the polymer surface modifications. The work was supported by the Office of Naval Research.
References:
1) E. H. Lock, J. Wojciechowski, S. H. North, S. G. Walton, C. R. Taitt, “Exploring the mechanism of biomolecule immobilization on plasma treated polymer substrate”, to be published NATO Science for Peace and Security Series by Springer.
2) S. H. North, E. H. Lock, C. J. Cooper, J. B. Franek, C. R. Taitt, S. G. Walton, “Plasma-based surface modification of polystyrene microtitre plates for covalent immobilization of biomolecules”, ACS Appl. Mater.& Interfaces 2, 2884-91 (2010).