AVS 57th International Symposium & Exhibition | |
Nanometer-scale Science and Technology | Monday Sessions |
Session NS-MoA |
Session: | Nanomaterials in the Environment |
Presenter: | A. Karakoti, University of Central Florida |
Authors: | A. Karakoti, University of Central Florida S. Kuchibhatla, Pacific Northwest National Laboratory G. Orr, Pacific Northwest National Laboratory H. Wang, Pacific Northwest National Laboratory D.R. Baer, Pacific Northwest National Laboratory S. Seal, University of Central Florida S. Thevuthasan, Pacific Northwest National Laboratory |
Correspondent: | Click to Email |
Topical interest in the biomedical applications of cerium oxide nanoparticles (CNPs) has emerged from its radical scavenging, antioxidant like, behavior. The ability of CNPs to carry these single electron redox processes (radical scavenging) stems from the ability of cerium to switch between the Ce3+ and Ce4+ oxidation states. It is essential to test and increase the biocompatibility and solubility of CNPs to be able to use these in biomedical applications as it involves a direct interface of nanoparticles with the intracellular environment. The biocompatibility as well as solubility of CNPs can be increased by modifying the surface with biocompatible polymers as ligands. Such a composite system should be able to demonstrate the unaltered characteristics of the parent CNPs and biocompatibility as well as high solubility of the polymeric system. Thorough characterization of CNP-polymer system such as thickness of polymeric coating, surface coverage and number density of the polymer per nanoparticle is necessary to relate its properties with biocompatibility.