Invited Paper BI2+NS-ThM9
Membranes on Solid Surfaces

Thursday, October 21, 2010, 10:40 am, Room Taos A

Lipid assemblies on solid substrates provide a means of integrating biological and non-biological systems. They serve as a basis for a number of technological applications, particularly biological sensing and imaging platforms. They also provide important materials for the study of fundamental biophysical processes, and additionally are a platform for the study of the structure and dynamics of low-dimensional complex fluids. Working with a number of collaborators [1-4], we have been investigating how lipids interact with variously textured and functionalized solid surfaces, with an emphasis on the use of optical microscopy and spectroscopy as means of interrogating structure, dynamics and function within membrane assemblies on surfaces. Selected examples from recent and ongoing work will be discussed, including the use of diffusion measurements to infer the nature of membrane interactions with nanotextured surfaces, preparation and characterization of controlled multi-bilayer architectures, study of how electrostatic interactions with surfaces affect the structure and asymmetry of membranes, the interaction of functionalized nanoparticles and nanomaterials with membranes, and the development and characterization of multicomponent membranes on patterned nanoporous and nanostructured substrates. All of these topics are related to long-term interests in the application of solid-substrate supported lipid assemblies in sensing and characterization of biological systems.

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