AVS 53rd International Symposium
    Surface Science Thursday Sessions
       Session SS-ThP

Paper SS-ThP23
Beam Damage on Drug Tablet during XPS Analysis

Thursday, November 16, 2006, 5:30 pm, Room 3rd Floor Lobby

Session: Surface Science Poster Session
Presenter: C.A.J. Kemp, Eli Lilly and Company
Authors: C.A.J. Kemp, Eli Lilly and Company
X. Dong, Eli Lilly and Company
Correspondent: Click to Email
It is a well-known phenomenon that certain samples are susceptible to beam damage during XPS analysis. Dry-formulated drug products usually contain, in addition to the active pharmaceutical ingredient (API), multiple excipients. It is of great interest to understand the potential for inadvertent sample alteration during the analysis of drug products using XPS. In the current study, the potential beam damage to a drug tablet was evaluated. The preliminary results revealed the discoloration of the analytical area on the tablet after it was exposed to a 15kV X-ray beam for 2 hours. By ToF-SIMS analysis it was found that the characteristic mass peak of the excipient mannitol was relatively lower in the spectra of the discolored area than in the spectra of the control area, when compared to the characteristic peak of API. It suggests that mannitol is more susceptible to beam damage than API under the typical XPS analysis conditions. The effect of API level, and different XPS analysis conditions on the extent of beam-induced damage will be further investigated.