In order to create high-content Integrated Quantitative Molecular Diagnostics (iQMD) chip, Biologic Application Specific Integrated Circuits (BioASICs) and quantum nanoplasmonic probes such as nanostructured surface enhanced Raman scattering (nSERS) substrates are developed. Soft-state BioASICs are created by connecting existing and novel microfluidic circuits for high-content experimental biology in new ways. We are creating a library of these "building blocks" to develop multifunctional biological microprocessors. To build a solid foundation of future high-speed micro- and nanofluidic bioprocessors for experimental systems biology and biomarker discovery, we have developed design rules and critical modules of BioASICs such as single cell analysis chip, integrated multiple patch-clamp array, dynamic cell culture array, on-chip cell lysing device, sample preparation chip, cell separation device, high-density single cell analysis chip, molecular harvesting device, cell-cell communication array, animals on a chip, and nanofluidic SERS substrate. For nanoscale spectroscopic molecular imaging and photothermal therapeutic applications, nanocrescent SERS probes are developed. The formation of asymmetric nanophotonic crescent structure is accomplished by the interfacing both bottom-up and top-down methods, which allows to create effective local field enhancement structures, batch nanofabrication, and precise controls of hot spot coupling distance for in-vivo molecular imaging. Gold-based nanocrescents have structures with a sub-10 nm sharp edge, which can enhance local electromagnetic field at the edge area. The advanced nanocrescent SERS probes can be applied for sensitive molecular detection and electron transfers of biomolecules. The functional BioASICs and quantum nanoplasmonics have a potential to impact on systems biology and quantitative medicine.