AVS 52nd International Symposium
    DNA Topical Conference Monday Sessions
       Session DN+BI-MoA

Paper DN+BI-MoA1
Diamond-based Electrical Biosensors for DNA Detection

Monday, October 31, 2005, 2:00 pm, Room 311

Session: DNA Detection and Sensing
Presenter: B. Sun, University of Wisconsin-Madison
Authors: B. Sun, University of Wisconsin-Madison
W. Yang, University of Wisconsin-Madison
H. Kim, University of Wisconsin-Madison
K.-Y. Tse, University of Wisconsin-Madison
J.N. Russell, Jr., Naval Research Laboratory
J.E. Butler, Naval Research Laboratory
R.J. Hamers, University of Wisconsin-Madison
Correspondent: Click to Email
The high stability of diamond makes an attractive material to use for interfacing microelectronics to biological molecules such as DNA. We have investigated the fabrication of diamond-based field-effect transistors in which the surface of the diamond is functionalized with biomolecules of interest, and binding to target molecules in solution produces a change in electrical properties via a field effect. Because the sensitivity depends on the size of the FET, our efforts have been placed on developing small devices, a few microns in size. Measurements in a field-effect transistor geometry can be compared to those made via impedance spectroscopy, as both are sensitive to the impedance of the diamond space-charge region. This talk will discuss the factors controlling the sensitivity and electrical stability of diamond-based electrical biosensing devices, as applied to DNA and other biomolecules.