AVS 52nd International Symposium
    Biomaterial Interfaces Monday Sessions
       Session BI-MoP

Paper BI-MoP8
Nanoscale Adhesion, Friction and Wear Studies of Biomolecules on Silicon Based Surfaces

Monday, October 31, 2005, 5:00 pm, Room Exhibit Hall C&D

Session: Biomaterial Interfaces Poster Session
Presenter: D.R. Tokachichu, The Ohio State University
Authors: D.R. Tokachichu, The Ohio State University
B. Bhushan, The Ohio State University
M.T. Keener, The Ohio State University
S.C. Lee, The Ohio State University
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Protein layers are deployed over the surfaces of synthetic microdevices like bioimplants and bioMEMS to facilitate biocompatibility with biological tissue. When a biosensor comes in contact with any exterior environment like tissues, or fluids with a variable pH, the biomolecules on the sensor surface may get abraded due to a change in the adhesion between the biomolecules and microdevice surface. Friction and wear properties of biomolecules (e.g. proteins) on silicon based surfaces are important because these devices come across wear and friction when they are introduced into these environments. Changes in adhesion have been studied between streptavidin and a thermally grown silica substrate in phosphate buffered saline (PBS) solution with various pH values as a function of concentration of immobilized biomolecules in solution. Wear and friction properties of streptavidin (protein) biomolecules coated on silica by direct physical adsorption and chemical linker method were studied in PBS using tapping mode AFM at a range of free amplitude voltages.