AVS 52nd International Symposium
    Biomaterial Interfaces Monday Sessions
       Session BI-MoP

Paper BI-MoP31
Effects of Surface Topography, Chemistry and Wettability on Osteoblast Cell Adhesion and Mineralization on Sol-Gel-Derived Titanium Alloy

Monday, October 31, 2005, 5:00 pm, Room Exhibit Hall C&D

Session: Biomaterial Interfaces Poster Session
Presenter: M.C. Advincula, University of Alabama at Birmingham
Authors: M.C. Advincula, University of Alabama at Birmingham
E.T. Ada, University of Alabama at Birmingham
F.G. Rahemtulla, University of Alabama at Birmingham
R.C. Advincula, University of Houston
S.L. Bellis, University of Alabama at Birmingham
J.E. Lemons, University of Alabama at Birmingham
Correspondent: Click to Email
The biological events occurring at the bone-implant interface are influenced by the topography, chemistry and wettability of the implant surface.The surface properties of titanium alloy Ti6Al4V prepared by surface sol-gel processing (SSP) were investigated systematically using x-ray photoelectron spectroscopy, scanning electron microscopy, atomic force microscopy and contact angle metrology. Biocompatibility of the oxide was assessed by evaluating MC3T3 osteoblastic cell adhesion to the substrate, as well as by matrix mineralization. The sol-gel coated surface had predominantly a TiO@sub 2@ composition with abundant hydroxyl OH- groups, and was highly wettable, with increased roughness and porosity. Significantly more cells adhered to the sol-gel, as compared with passivated surfaces, at 1 and 24 hours following cell seeding, and a markedly greater number of bone nodules were observed on sol gel coatings. Favorable cellular responses were attributed to the rougher porous surface, hydrophilicity and increased hydroxyl group content of the sol gel, properties which, in turn, are known to regulate the adsorption of pro-adhesive serum proteins onto material surfaces.Collectively our results show that surface properties of titanium alloy can be modified by SSP to further enhance the bioactivity of this biomaterial.