AVS 52nd International Symposium
    Biomaterial Interfaces Monday Sessions
       Session BI-MoP

Paper BI-MoP18
Syntheses of Polymer-Protein Composites by Plasma-Spinning Deposition

Monday, October 31, 2005, 5:00 pm, Room Exhibit Hall C&D

Session: Biomaterial Interfaces Poster Session
Presenter: R. Ohta, Nagoya University, Japan
Authors: R. Ohta, Nagoya University, Japan
N. Saito, Nagoya University, Japan
O. Takai, Nagoya University, Japan
Correspondent: Click to Email
Blood and/or tissue contacting biomaterials as catheters, artificial blood vessels and artificial valves are desired to have higher biocompatibilities in the medical field. Therefore, polymer-protein composites, which are expected to have excellent biocompatible surfaces, have been attracting attentions of many researchers. In this research, we aimed to synthesize polymer-protein composites by plasma-spinning deposition (PSD). In the PSD, the polymer composites were synthesized from precursor solutions. The precursor solutions were filled in a metallic capillary tube. Plasma were produced by applying voltages to the capillary tube. The polymer composites were synthesized on substrates from the precursors, which passed through the plasma. Two different processes were examined to synthesize the polymer-protein composites: (i) PSD of the polymer-protein composites from mixed solvents of the precursor polymers and proteins, and (ii) immobilization of proteins to the polymers synthesized by the PSD. Polyethylene terephthalate (PET), polyurethane (PU) and polyacrylonitrile (PAN) were used as precursor polymers. Proteins as fibrinogen, heparin and albumin were contained into the polymer composites. The PSD process was optimized by varying the concentrations of the polymers and proteins in the precursor solutions and by controlling the plasma states during the PSD. The chemical structures of the polymer-protein composites were analyzed by spectroscopic methods as X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy (RS), etc. The surface characteristics of the polymer-protein composites were investigated by scanning electron microscope (SEM), atomic force microscope (AFM), etc.