AVS 52nd International Symposium
    Biomaterial Interfaces Monday Sessions
       Session BI-MoP

Paper BI-MoP16
Materials Characterization for Blood-Flow Dynamics and Platelet-Adhesion Simulation of Hematocompatible Plasma-Polymerized Tetraglyme Surfaces

Monday, October 31, 2005, 5:00 pm, Room Exhibit Hall C&D

Session: Biomaterial Interfaces Poster Session
Presenter: E. Hanley, University of Wisconsin-Madison
Authors: E. Hanley, University of Wisconsin-Madison
J.L. Shohet, University of Wisconsin-Madison
J.L. Lauer, University of Wisconsin-Madison
R.M. Albrecht, University of Wisconsin-Madison
S. Esnault, University of Wisconsin-Madison
J.S. Malter, University of Wisconsin-Madison
R.H. Blick, University of Wisconsin-Madison
H.S. Kim, University of Wisconsin-Madison
U. von Andrian, Harvard Medical School
S.B. Shohet, University of California, San Francisco
Correspondent: Click to Email
The realization of small-scale biomedical devices will be closely related to the non-fouling/biocompatible properties of the exposed surfaces and the uniformity of the surface treatment throughout the device. Thrombus formation and embolization are significant problems for blood-contacting biomedical devices which often begin with platelet adhesion. In this work, we explore plasma polymerization (PP) to improve the hematocompatibility of silicon-based surfaces and the process conditions necessary to develop a uniform PP coating on the lumenal surface of artificial blood vessels. To minimize these effects, plasma-polymerized tetraglyme was deposited on flat Si@sub 3@N@sub 4@ and SiO@sub 2@ samples to produce a PEO-like surface coating. The dynamics of platelets can be modeled using a numerical simulation of adhesive particles interacting with an adhesive surface.@footnote 1@ Experimentally, emitted light from the plasma during the PP process was fed into a monochromator. Coating thickness and chemical composition of the surfaces was measured using ellipsometry and XPS, respectively. Contact-angle measurements were carried out on the PP surfaces. An atomic force microscope was used to determine the surface topology of the coated PP surface. To test platelet adhesion, the PP surfaces were exposed to heparinized human blood. After blood exposure, a scanning electron microscope was utilized to assess the density of adhering platelets on the PP surfaces. The plasma-treated surfaces showed fewer blood adherents than the untreated surfaces. The simulation can include the surface topology as measured by the AFM. By suitably modifying the plasma parameters, the plasma-polymerization treatment can be optimized with the eventual goal of producing biocompatible, small-diameter (< 5 mm ID) artificial blood vessels that contain integrated sensor systems. @FootnoteText@ @footnote 1@M.R. King and D.A. Hammer, Biophys. J. v.81, 799-813 (2001).