AVS 52nd International Symposium
    Biomaterial Interfaces Friday Sessions
       Session BI+SS-FrM

Paper BI+SS-FrM3
Chemical Interaction Analysis of Adhesive Biomaterial-Hard Tissue Interfaces

Friday, November 4, 2005, 9:00 am, Room 311

Session: Biomaterials Surface Characterization
Presenter: Y. Nakayama, Toray Research Center, Inc., Japan
Authors: Y. Nakayama, Toray Research Center, Inc., Japan
Y. Yoshida, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
K. Suzuki, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
B. Van Meerbeek, Catholic University of Leuven, Belgium
Correspondent: Click to Email
Adhesion to human hard tissue plays an important role in both dental and orthopedic therapies. Synthesized adhesive biomaterials made of polymer, as well as of functional monomer, have been developed. Among such adhesive biomaterials, those capable of forming chemical bond with hard tissue such as dentin, enamel or hydroxyapatite (HAp) are more appreciated for achieving more durable adhesion. Evidence of chemical bonding at biomaterial-hard tissue interfaces was recently reported for interfaces between polyalkenoic acid and enamel or HAp with the use of high resolution X-ray Photoelectron Spectroscopy (XPS).@footnote 1@ Preparation of ultrathin biomaterial molecular layer on enamel or HAp substrate enabled high resolution XPS spectrum to distinguish carboxylic carbons with chemical bond to HAp from those without chemical bond at the interface. Chemical interaction of carboxylic acids with HAp was analyzed and adhesion-decalcification concept (AD concept) was proposed.@footnote 2@ According to the AD concept, the less soluble the calcium salt of the acidic molecule, the more intense and stable the molecular adhesion to a hydroxyapatite-based substrate. Subsequently, adhesive performance of functional monomers, such as those containing dihydrogen phosphate or carboxylic acid, with HAp and dentin was studied.@footnote 3@ In this presentation, we will report chemical interaction analysis of functional monomer-hard tissue interfaces by utilizing high resolution XPS and relating analytical data. @FootnoteText@ REFERENCES:@footnote 1@ Y.Yoshida, B.Van Meerbeek, Y.Nakayama, J.Snauwaert, L.Hellemans, P.Lambrechts, G.Vanherle, K.Wakasa: J.Dent.Res., 79, 709 (2000).@footnote 2@ Y.Yoshida, B.Van Meerbeek, Y.Nakayama, M.Yoshioka, J.Snauwaert, Y.Abe, P.Lambrechts, G.Vanherle, M.Okazaki: J.Dent.Res., 80, 1565(2001) .@footnote 3@ Y.Yoshida, K.Nagakane, R.Fukuda, Y.Nakayama, M.Okazaki, H.Shintani, S.Inoue, Y.Tagawa, K.Suzuki, J.De Munck, B.Van Meerbeek: J.Dent.Res., 83, 454(2004) .