AVS 51st International Symposium
    Biomaterial Interfaces Thursday Sessions
       Session BI+AS+SE-ThM

Invited Paper BI+AS+SE-ThM3
Interfacial Biomaterials: Guiding Biology on Synthetic Surfaces

Thursday, November 18, 2004, 9:00 am, Room 210D

Session: Surface Modification of Biomaterials
Presenter: D.J. Kenan, Duke University Medical Center
Authors: E.B. Walsh, Duke University
X. Huang, Duke University
M.W. Grinstaff, Boston University
D.J. Kenan, Duke University Medical Center
Correspondent: Click to Email
Interfacial biomaterials represent a novel coating technology capable of directing biological processes at the interface between a biologic and a synthetic surface. The approach relies on screening combinatorial libraries to identify unique peptides that adhere to a synthetic target such as a plastic or metal, or to a biological target such as a protein or cell. Next, two or more adhesion peptides are synthetically coupled to create an interfacial biomaterial that mediates the interaction of the protein or cell with the synthetic material. Other interfacial biomaterials may be created by coupling known signaling molecules to peptides that bind synthetic materials. Mixtures of interfacial biomaterials may be applied to a surface to achieve a particular desired biological outcome, such as adhesion of a given cell type to the surface, followed by induction of one or more signal transduction pathways. These interfacial biomaterials are amenable to numerous coating and patterning techniques suggesting their use for diverse applications ranging from biomedical device coatings to anti-infectives to tissue engineering.