Fluid handling integrated into microsystems has been in use now for a number of years. Mostly, research has focused on micro pumps, valves, sensor flow cells and electrophoresis.@footnote 1,2,3@ However, the underlying idea of shrinking the whole analytical chemistry or biochemistry lab down to chip size will make it necessary to talk about interfacing these modules properly and efficiently. Recently, we have proposed a concept for a chemical microprocessor.@footnote 4,5@ This concept is related to an earlier attempt to define an analytical chemistry microsystem, micro-TAS (miniaturised total analysis system).@footnote 6@ Scaling laws predict 100x faster mass and heat transport, if a known system is miniaturized by a factor 10 (linear). This is particularly useful in capillary electrophoresis, chromatography and continuous-flow reactors. We have presented several examples in the past few years. I plan to show a few examples of recent chip developments taken from my lab: A horseradish peroxidase assay (400ms incubation), isoelectric focusing of a peptide in continuous flow (100x higher concentration in 300ms focusing time) and an air monitor based on a plasma emission chip. @FootnoteText@ references @footnote 1@Micro Total Analysis Systems 2000, A.van den Berg, W.Olthuis, P.Bergveld, eds., Kluwer Academic Press, ISBN 0-7923-6387-6 (2000). @footnote 2@D.R.Reyes, D.Iossifidis, P.A.Auroux, A.Manz, Anal Chem 74, 2623-2636 (2002) @footnote 3@P.A.Auroux, D.Iossifidis, D.Reyes, A.Manz, Anal Chem 74, 2637-2652 (2002) @footnote 4@A.Manz, H.Becker, Transducers 97, Chicago, June 16-19, 1997, Digest of technical papers (1997) 915-918. @footnote 5@M.C.Mitchell, V.Spikmans, A.Manz, A.J.de Mello, J.Chem.Soc., Perkin Trans.1 2001 (2001) 514-518. @footnote 6@A.Manz, N.Graber, H.M.Widmer, Sens. Actuators B1 (1990) 244-248.