AVS 50th International Symposium
    Biomaterial Interfaces Friday Sessions
       Session BI+PS-FrM

Paper BI+PS-FrM7
Growth of Biodegradable Thin Films by Methods of Pulsed Laser Deposition

Friday, November 7, 2003, 10:20 am, Room 318/319

Session: Plasma Methods for Bio-interfaces
Presenter: J.M. Fitz-Gerald, University of Virginia
Authors: J.M. Fitz-Gerald, University of Virginia
A.L. Mercado, University of Virginia
L. Zhigilei, University of Virginia
R. Johnson, University of Virginia
C.L. Fraser, University of Virginia
J.D. Talton, Nanotherapeutics, Inc.
Correspondent: Click to Email
Poly(DL-lactide-co-glycolide) (PLGA) is a biodegradable polymer with application in many areas of biomedical field ranging from contact lenses to sustained drug release formulation. In this research thin films (25 nm - 5 microns) of PLGA were deposited onto Si and NaCl wafers, in addition, a specific class of particulate materials (inhaled steroids) ranging from 1-5 microns in size were coated for in-vitro testing. All coatings were processed by both conventional pulsed laser deposition (PLD) and matrix-assisted pulsed laser evaporation (MAPLE) techniques. Film morphology, chemical structure, and decomposition effects were characterized by scanning electron microscopy (SEM), Fourier transform infrared infrared spectroscopy (FTIR), gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), and in-vitro dissolution.