AVS 49th International Symposium
    Surface Science Tuesday Sessions
       Session SS-TuP

Paper SS-TuP20
Adsorption of Vesicles to Titanium Dioxide: Effect of Vesicle Size and Lipid Composition

Tuesday, November 5, 2002, 5:30 pm, Room Exhibit Hall B2

Session: Surface Science Poster Session
Presenter: I. Reviakine, University of Houston
Authors: I. Reviakine, University of Houston
F. Rossetti, ETH Zurich, Switzerland
A.N. Morozov, University of Leiden, The Netherlands
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Adsorption of intact vesicles has been shown to be the first step in the formation of supported phospholipid bilayers.@footnote 1,2@ While the process of supported bilayer formation has been investigated in significant detail, that of vesicle adsorption has received much less attention. Experimental@footnote 2@ and theoretical@footnote 3@ studies indicate that the extent of deformation of the adsorbed vesicles determines whether they will form a Supported Vesicular Layer (SVL) or a Supported Phospholipid Bilayer (SPB). Bending rigidity of the bilayer and vesicle size control the extent of vesicle deformation on a given surface. This study has therefore focused on investigating the effect of these two parameters on the properties of an SVL formed on the surface of TiO@sub 2@, where vesicles used in this study adsorbed but did not form SPBs. A combination of spectroscopic (Quartz Crystal Microbalance with Dissipation measurement, QCM-D) and microscopic (Atomic Force Microscopy) techniques was used to follow the adsorption process. Voight model was used to interpret QCM-D response @footnote 4@ and the results were compared with the Random Sequential Adsorption model. @FootnoteText@ @footnote 1@ Keller and Kasemo, Biophys J. 1998, 75, 1397.@footnote 2@ Reviakine and Brisson, Langmuir 2000, 16, 1806.@footnote 3@ Seifert U., Adv. Phys. 1997, 46, 13.@footnote 4@ Voinova et al., Physica Scripta 1999, 59, 391.