This briefing describes the Defense Threat Reduction Agency's (DTRA) efforts to accelerate research and development programs for combating terrorism. DTRA is a combat support agency providing a unique blend of operational and technical expertise and experience to reduce weapons of mass destruction threats. DTRA's Technology Development portfolio includes programs in nuclear weapon effects technology, integrated systems applications that include advanced concept technology demonstrations, counterproliferation technology, and nonproliferation and arms control technology. Technology challenges include the detection of dispersed and non-dispersed nuclear, chemical and biological threats, remote detection of weapons of mass destruction, force protection technologies, microscale hazard prediction, information management, hard and deeply buried target defeat, and agent defeat.