IUVSTA 15th International Vacuum Congress (IVC-15), AVS 48th International Symposium (AVS-48), 11th International Conference on Solid Surfaces (ICSS-11)
    Biomaterials Thursday Sessions
       Session BI-ThP

Paper BI-ThP14
Ion Implanted Titanium: Relating Surface Chemistry to Cellular Response.

Thursday, November 1, 2001, 5:30 pm, Room 134/135

Session: Biomolecule and Cell Poster Session
Presenter: F.H. Jones, University College London, UK
Authors: F.H. Jones, University College London, UK
L. Shinawi, University College London, UK
S. Nayab, University College London, UK
I. Olsen, University College London, UK
J.A. Hobkirk, University College London, UK
T.J. Tate, Imperial College of Science, Technology and Medicine, UK
D.S. McPhail, Imperial College of Science, Technology and Medicine, UK
Correspondent: Click to Email
Titanium-based materials are used extensively in hard tissue biomedical implants, often with inorganic coatings to promote bone regeneration and integration. The properties of such coatings remain less than ideal; variable composition, dissolution at low pH and fracture failure or delamination continue to present serious problems. Direct modification of the surface using ion implantation has been proposed as a possible alternative, giving a favourable interface for interaction with the host tissue, without affecting bulk properties. The homogeneity and controllability of ion implantation also mean that the technique is ideal for studying the fundamental effects of chemical composition on cellular response to a surface. Ca implantation has been shown to promote osseointegration,@footnote 1@ but little attention has been paid to the effect of the nature of the substrate on the resulting surface chemistry, or the difference in behaviour of surfaces implanted with different ions. The current work examines the effect of ion implantation into native Ti, air oxidised Ti and TiO@sub 2@ single crystals. Ca, K and Ar ions, selected due to their similar masses, were implanted at doses up to 2x10@super 17@ ions cm@super -2@. Preliminary cell culture studies indicate significant differences in cell behaviour depending on the chemical nature of the implanted ion. Of particular interest are adverse effects observed on Ar-implanted surfaces, despite the inert nature of argon. In parallel, XPS and SIMS were used to investigate surface chemistry. The effects of annealing in UHV and immersion in water were found to be element-dependent. The nature of the ion was also found to influence the interaction with model organic species in solution and the rate of calcium phosphate deposition from mineralising solutions. @FootnoteText@ @footnote 1@ Hanawa T, Kamiura Y, Yamamoto S, Kohgo T, Amemiya A, Ukai H, Murakami K, Asaoka K. J. Biomed. Mater. Res. 36 (1997) 131.