IUVSTA 15th International Vacuum Congress (IVC-15), AVS 48th International Symposium (AVS-48), 11th International Conference on Solid Surfaces (ICSS-11)
    Biomaterials Thursday Sessions
       Session BI-ThP

Paper BI-ThP11
Self-Assembly Approaches to Preparation of Self-Supported Porous Films for Selective Cell Separations and Tissue Engineering Scaffolds

Thursday, November 1, 2001, 5:30 pm, Room 134/135

Session: Biomolecule and Cell Poster Session
Presenter: M. Tanaka, Hokkaido University, Japan
Authors: M. Tanaka, Hokkaido University, Japan
M. Miyama, Hokkaido University, Japan
K. Nishikawa, Hokkaido University, Japan
J. Nishida, Hokkaido University, Japan
M. Shimomura, Hokkaido University, Japan
Correspondent: Click to Email
Selective cell separation is one of the most important issues in the field of tissue regenerative medicine at present. We prepared self-supported porous films of poly(@beta@caprolactone) or poly(lactic acid-co-glicolic acid) with wide range of controlled pore size (0.5-100 µm) and area (diameter 1-20 cm) to develop high-performance filters and tissue engineering scaffolds. The self-supported porous films were fabricated by a simple casting technique and self-assembly proceses@footnote 1,2@ without lithographic methods. The films had highly regular patterns and stable net structure with high mechanical stability and moderate elasticity. Creation of desirable pore size was easy, and the pore size can be controlled simply by changing the evaporation rate of the polymer solutions. The porous film which had been a novel biocompatible poly(2-methoxyethyl acrylate)@footnote 3,4@ coated was attached to a module having an inlet port and outlet port to simulate a leukocyte eliminating. The film provided the 100% selective separation of the leukocyte from human blood. The leukocyte eliminating ratio and platelet recovery were dependent on the pore structures (size and depth) and the chemical properties (hydrophilicity and surface charge). The biocompatible and biodegradable films could be expected as promising materials to produce useful selective cell separations, implants and cell-supported elastic scaffold for various medical devices. @FootnoteText@@footnote 1@N. Maruyama et al., Thin Solid Films, 327-329, 854-856 (1998) @footnote 2@T. Nishikawa et al., Mater. Sci. & Eng. C, 10, 141-146 (1999) @footnote 3@M. Tanaka et al., Biomaterials, 21, 1471-1481 (2000) @footnote 4@M. Tanaka et al., Polymer Int, 49, 1709-1713 (2000)